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Comparison of WAP and DEG scores reproducibility in eighteen large gene expression data sets representing eight diseases.

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posted on 2020-02-14, 18:33 authored by Joël R. Pradines, Victor Farutin, Nicholas A. Cilfone, Abouzar Ghavami, Elma Kurtagic, Jamey Guess, Anthony M. Manning, Ishan Capila

A-H: Each data set is randomly split in two sets one thousand times, and the resulting distributions of overlap statistic maxR are estimated for WAP scores (blue), PFP values of WAPs (pink), DEG scores (green) and WAP scores with randomly rewired protein network (brown). Vertical bars display 99% confidence intervals on median values estimated by bootstrapping with 106 samples. I: summary of results over 18 data sets for distributions of maxR differences between DEG and WAP scores (paired values of maxR in each partition (WAP versus DEG scores)).

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