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Comparison of 18F-FSPG, 18F-FET and 18F-FDG uptake in rat GS9L brain tumors, healthy brain and blood at approximately 1 hr post injection.

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posted on 2016-02-18, 15:54 authored by Erik S. Mittra, Norman Koglin, Camila Mosci, Meena Kumar, Aileen Hoehne, Khun Visith Keu, Andrei H. Iagaru, Andre Mueller, Mathias Berndt, Santiago Bullich, Matthias Friebe, Heribert Schmitt-Willich, Volker Gekeler, Lüder M. Fels, Claudia Bacher-Stier, Dae Hyuk Moon, Frederick T. Chin, Andrew W. Stephens, Ludger M. Dinkelborg, Sanjiv S. Gambhir

The tracer uptake was measured ex vivo and is shown as % ID/g values with standard deviation and ranges. Tumor-to-normal brain (T/brain) and tumor-to-blood ratios (T/blood) were derived from the respective mean values.

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    measure xCimaging orthotopic brain tumorsratioorthotopic brain tumorssafety parametersmetastatic brain cancerintracranial malignanciestumor uptakebrain metastasesfuture studiessubjectGS 9L model300 MBqFischer ratsglutamate analoguetumor visualizationbrain tumorsage 50.4 yearsClinical Evaluationanimal studyCTPositron Emission Tomographyanimal model.Conclusions 18Fscanbackground signalPilot PreclinicalGS 9L glioblastoma cellsintracranial malignancies.Experimental DesignForbrain tumortransporter activitypilot studyNCTnovel PET

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