Changes in frequency (cells/ml) of BM subsets induced by wt S. Typhi infection.

BM subsets (IgD/CD27 classification) were evaluated for changes in frequency (cells/ml) elicited by exposure to wt S. Typhi. Panels A, D, G and J display the time courses of the changes in Sm CD27+, Sm CD27-, Um and Naïve cells, respectively, in TD and NoTD volunteers (blue and brown simbols, respectively). The AroundTD time frame is indicated in panels A, D, G and J by the blue rectangles with dotted lines. Panels B, E, H and K shown changes in Sm CD27+, Sm CD27-, Um and Naïve subsets, respectively, from TD (solid blue circles) and NoTD (solid brown squares) volunteers in the AroundTD time frame. Panels C, F, I and L, show changes in Sm CD27+, Sm CD276-, Um and Naïve subsets, respectively, from TD (open blue circles) and NoTD (open brown squares) in the AfterTD time frame. The P value from the mixed effects model analysis is shown. Significant differences are highlighted in light green. Mean ± SD are presented in all graphs.