pone.0218649.g002.tif (1.01 MB)
Calibration of the deterministic model and the stochastic individual-based model.
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posted on 2019-07-03, 20:05 authored by Ume L. Abbas, Robert L. Glaubius, Yajun Ding, Gregory HoodModel calibration to HIV prevalence among (A) women and (B) men by age. Error bars show 95% confidence intervals for data and 95% credible intervals for the IBM model (imperceptible because narrow) and ODE model (posterior) estimates. C: Model calibration to HIV incidence in the ACDSS and comparison to the UNAIDS’ Spectrum model [40]. D: Model validation against HIV prevalence in KwaZulu-Natal among adults aged 15–24 and 15–49 from the four South African national household surveys [7]. Abbreviations: ODE, ordinary differential equation; IBM, individual based model; ACDSS, Africa Centre Demographic Surveillance Site; CrI, credible interval.
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first-line antiretroviral therapyHeterosexual HIV epidemicHIV drug resistancealternative first-line regimensM 184V K 65Rmodeling study Background Tenofovir-containing regimensdrug resistance levelstenofovir-containing first-line ARTNNRTICD 4-based ARTConsiderable HIV drug resistanceIQRdrug resistanceincident infectionsK 65R mutations
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