CNS—neuronal canonical and non-canonical pathways observed to be regulated by mTBI compared to sham, and the effects of post-injury treatment with phenserine on mTBI-regulated pathways are presented.

R* refers to Reactome. Most pathways were observed to be down regulated by mTBI, with only two that were up regulated. Two pathways were associated with neurodegenerative disease: ‘Blalock Alzheimer’s Disease Up’ and ‘Biocarta Parkin Pathway’. While post-injury treatment of animals with phenserine had no effect on the majority of pathways, one Alzheimer’s disease-related pathway was further regulated by this drug. Drug treatment reversed the effects of mTBI on the Alzheimer’s disease pathway.