Fig 5.TIF (690.15 kB)
CNS—neuronal canonical and non-canonical pathways observed to be regulated by mTBI compared to sham, and the effects of post-injury treatment with phenserine on mTBI-regulated pathways are presented.
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posted on 2016-06-02, 03:45 authored by David Tweedie, Koji Fukui, Yazhou Li, Qian-sheng Yu, Shani Barak, Ian A. Tamargo, Vardit Rubovitch, Harold W. Holloway, Elin Lehrmann, William H. Wood III, Yongqing Zhang, Kevin G. Becker, Evelyn Perez, Henriette Van Praag, Yu Luo, Barry J. Hoffer, Robert E. Becker, Chaim G. Pick, Nigel H. GreigR* refers to Reactome. Most pathways were observed to be down regulated by mTBI, with only two that were up regulated. Two pathways were associated with neurodegenerative disease: ‘Blalock Alzheimer’s Disease Up’ and ‘Biocarta Parkin Pathway’. While post-injury treatment of animals with phenserine had no effect on the majority of pathways, one Alzheimer’s disease-related pathway was further regulated by this drug. Drug treatment reversed the effects of mTBI on the Alzheimer’s disease pathway.
