Body weights, serum and renal biochemical determinations in mice with AAI-induced acute nephropathy.
Animal model of nephropathy was performed in C57BL/6 mice. The mice were treated with AAI via intraperitoneal (i.p.) injection, and the accumulated AAI dosage was 45 mg/kg BW (15 mg/kg BW per day for 3 days). Five groups of 9 mice per group were used. Mouse body weights were recorded daily (A), changes in serum BUN and creatinine (B) levels, and urine protein and urine albumin (C) levels were determined. All values are expressed as the means ± SD of each group (n = 9). ** indicates p < 0.01 compared to the Control group; † and †† indicate p < 0.05 and p < 0.01 compared to the AAI group, respectively.