Analytes with significant interactions between log2-transformed serum concentration and sex in MDD compared to controls.

The natural logarithm of the odds ratio (OR; the ratio of the odds of MDD diagnosis associated with a two-fold increase in the untransformed serum concentration of that analyte from the logistic model) is shown for males and females with 95% confidence intervals. P- and q-values (FDR-adjusted p-values) are shown for the interaction tests. Abbreviations: OR (odds ratio); Q (q-value, FDR-adjusted p—value); TFF3 (trefoil factor 3); IGFBP (insulin-like growth factor binding protein); B2M (β2-microglobulin); uPAR (urokinase-type plasminogen activator receptor); FABP (fatty acid-binding protein); TBG (thyroxine-binding globulin); HGF (hepatocyte growth factor); vWF (von Willebrand factor); PPP (pancreatic polypeptide); TN-C (tenascin-C); CRP (C-reactive protein); CD5L (CD5 antigen-like); OPG (osteoprotegerin); TNFR2 (tumor necrosis factor receptor 2); VCAM (vascular cell adhesion molecule); FAS (FASLG receptor); MDC (macrophage derived chemokine); PARC (pulmonary and activation-regulated chemokine); MMP (matrix metalloproteinase); MIP-3B (macrophage inflammatory protein-3β); IL-2RA (interleukin-2 receptor α). † Eotaxin-1 was no longer significant when analyzed using multiple imputation (see S4 Table).