pone.0202150.g004.tif (647.16 kB)
Adipose tissue inflammation is slightly increased in macrophage CD40 deficient mice without resulting in altered cytokine release.
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posted on 2018-08-10, 17:39 authored by Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens(A) Quantification of CD45 staining for leukocytes of EpAT (n = 16 for HFD and n = 7 for SFD). (B) Quantification of Mac3 staining for macrophages in EpAT (n = 16 for HFD and n = 7 for SFD). (C) Quantification of CD3+ staining for T cells in EpAT (n = 16 for HFD and n = 7 for SFD). (D) Flow cytometric analysis of leukocyte subsets in EpAT, as % of total CD45+ leukocytes (n = 7-9/group). (E) mRNA expression of inflammatory markers in EpAT (n = 7-9/group). Data is presented as mean ± SEM.
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adipose tissue leukocyte infiltrationWT40LMacrophage CD 40SFDadipose tissue inflammation40-CDameliorates adipose tissue inflammationinsulin resistanceHFDCD 40 flfl LysM creincreases insulin sensitivitymacrophage CD 40adipose tissue weightDIOplasma adiponectin levelstriglyceride levelsmacrophage CD 40. CD 40 flfl LysM cre miceadipose tissue cytokine levels
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