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A role of Eiger/TNFα in intra-organ growth.

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posted on 2019-08-19, 17:36 authored by Juan A. Sanchez, Duarte Mesquita, María C. Ingaramo, Federico Ariel, Marco Milán, Andrés Dekanty

(A) Representative adult wings from individuals expressing the indicated transgenes in posterior compartment (blue) under the control of en-Gal4. The expected size of the neighboring domain to give rise to a well-proportioned adult wing is shown. (B) Histogram plotting normalized area of the posterior (P; blue bars) and anterior (A; grey bars) compartments of adult wings from individuals expressing the indicated transgenes with en-Gal4. Expression of Dmp53RNAi, eigerRNAi or eigerIR reverted the non-autonomous reduction in tissue size caused by RA expression. ** p<0.01. (C-H) Wing discs expressing GFP along with RACS in the posterior compartment by using en-Gal4 in different genetic backgrounds (wild-type (C,F), co-expressing eigerRNAi (D,G) or eiger3/3 (E,H)) and labeled to visualize GFP (green), TUNEL (red in C-E; grey in C’-E’) and BrdU incorporation (red in F-H; grey in F’-H’).

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