A model outlining the cross-regulatory interactions between epidermal YAP, ROCK, β-catenin and Hh signalling.

(A) Epidermal SmoM2 activates YAP, ROCK signalling and dermal fibroblasts in the dorsal skin of K14-CreER/Rosa-SmoM2 transgenic mice (based on Figs 1 and 2). (B) Epidermal YAP activates GLI2 mediated by β-catenin activation in the dorsal skin of YAP2-5SA-ΔC transgenic mice (based on Figs 3 and 4). (C) A model outlining the proposed regulatory interactions between epidermal YAP, Hedgehog and ROCK-dependent mechanosignalling to balance skin regeneration based on our findings (red arrows) and on cited studies [25, 27, 29, 34, 39, 40, 45, 47, 48, 63, 64, 65, 66, 69].