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A model outlining the cross-regulatory interactions between epidermal YAP, ROCK, β-catenin and Hh signalling.

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posted on 2017-08-18, 17:23 authored by Bassem Akladios, Veronica Mendoza Reinoso, Jason E. Cain, Taopeng Wang, Duncan L. Lambie, D. Neil Watkins, Annemiek Beverdam

(A) Epidermal SmoM2 activates YAP, ROCK signalling and dermal fibroblasts in the dorsal skin of K14-CreER/Rosa-SmoM2 transgenic mice (based on Figs 1 and 2). (B) Epidermal YAP activates GLI2 mediated by β-catenin activation in the dorsal skin of YAP2-5SA-ΔC transgenic mice (based on Figs 3 and 4). (C) A model outlining the proposed regulatory interactions between epidermal YAP, Hedgehog and ROCK-dependent mechanosignalling to balance skin regeneration based on our findings (red arrows) and on cited studies [25, 27, 29, 34, 39, 40, 45, 47, 48, 63, 64, 65, 66, 69].

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