A Dmp53-mediated two-step mechanism regulates growth and proliferation in adjacent populations through the production of systemic and local signals.

Targeted expression of RA or depletion of dMyc activates Eiger-JNK signaling downstream of Dmp53. JNK-dependent expression of Dilp8 plays a crucial role in systemically coordinating the size of adjacent cell populations. On the other hand, JNK-dependent ROS production acts locally to regulate proliferation rates in adjacent cell populations.