ANGPTL8 treatment is well tolerated in mice.

(a) Timeline indicating blood glucose sampling, EdU labeling, tail vein injection of MBP or MBP+hBT on day 1 and 2, with sacrifice on day 3. (b-c) Initial (white circles) and final (black circles) (b) body weight (g) and (c) blood glucose (mg/dl). Two-way ANOVA was performed. (d-e) Random fed serum (d) insulin (ng/ml) and (e) triglycerides (mg/dl). Data are mean ± SEM. Buffer, no EdU and buffer, EdU = 4–5 animals per group; MBP and MBP+hBT = 10 animals per group. One-way ANOVA was performed.