10.1371/journal.pone.0221477.g001 Danielle van Keulen Danielle van Keulen Marianne G. Pouwer Marianne G. Pouwer Valur Emilsson Valur Emilsson Ljubica Perisic Matic Ljubica Perisic Matic Elsbet J. Pieterman Elsbet J. Pieterman Ulf Hedin Ulf Hedin Vilmundur Gudnason Vilmundur Gudnason Lori L. Jennings Lori L. Jennings Kim Holmstrøm Kim Holmstrøm Boye Schnack Nielsen Boye Schnack Nielsen Gerard Pasterkamp Gerard Pasterkamp Jan H. N. Lindeman Jan H. N. Lindeman Alain J. van Gool Alain J. van Gool Maarten D. Sollewijn Gelpke Maarten D. Sollewijn Gelpke Hans M. G. Princen Hans M. G. Princen Dennie Tempel Dennie Tempel <i>OSM</i>, <i>OSMR</i> and <i>LIFR</i> mRNA expression is present in human atherosclerotic plaques. Public Library of Science 2019 AGES LIFR Ly -6C High monocytes artery Leukemia Inhibitory Factor Receptor atherosclerosis development Oncostatin M APOE atherosclerotic lesion size plasma E-selectin levels results Gene expression analysis Chronic OSM administration OSMR serum OSM levels post incident CHD survival probability 2019-08-28 17:33:40 Figure https://plos.figshare.com/articles/figure/_i_OSM_i_i_OSMR_i_and_i_LIFR_i_mRNA_expression_is_present_in_human_atherosclerotic_plaques_/9744134 <p>mRNA expression was measured in normal arteries and in carotid plaques by microarray analysis (A-C) and ISH was used to visualize <i>OSM</i>, <i>OSMR</i> and <i>LIFR</i> mRNA expression (red spots and shown by the black arrows) in two different stages of atherosclerosis development, the late fibroatheroma (D-I) and intimal xanthoma (J-O). A two-sided Student’s t-test assuming non-equal deviation was used to test for significance between normal and atherosclerotic arteries. ***p<0.001, ****p<0.0001.</p>