Irie, Hiroyuki Yamamoto, Io Tarumoto, Yusuke Tashiro, Sanki Runge, Kurt W. Ishikawa, Fuyuki Regulation of GCRs by individual telomere binding proteins. <p>(A) Schematic representation of the <i>S</i>. <i>pombe</i> shelterin complex. (B) GCR rates of telomere-binding protein mutants. (C) Numbers of different types of GCRs identified in 5-FOA/FUdR-resistant clones derived from strains with the indicated genetic backgrounds. (D) Distribution of GCR (exclusively deletion types) junctions in the breakpoint region. Each arrowhead represents the location of a junction in the 5-FOA/FUdR-resistant clones. (E) GCR rates of <i>poz1</i>Δ and <i>tpz1-I501A/R505E</i> mutants in wild-type, <i>taz1</i>Δ, and <i>rap1</i>Δ backgrounds. Asterisks represent a statistically significant difference (P < 0.05) from the wild-type strain, unless otherwise noted. NS: non-significant (P > 0.05). P-values were determined by the two-tailed Mann–Whitney test.</p> GCR rates;RAP 1 homologues;chromosomal rearrangements;fission yeast Genomic rearrangements;telomere length homeostasis;shelterin components Taz 1;I-SceI-mediated DSB-induction experiments;TRF;Telomere-binding proteins Taz 1;Poz 1-binding domain;cause cell death;chromosome;fission yeast cells;shelterin-mediated telomere functions;Rap 1;DSB repair 2019-08-27
    https://plos.figshare.com/articles/figure/Regulation_of_GCRs_by_individual_telomere_binding_proteins_/9737990
10.1371/journal.pgen.1008335.g002