%0 Figure %A Chen, Li-Hao %A L. Advani, Suzanne %A Thai, Kerri %A Golam Kabir, M. %A M. Sood, Manish %A W. Gibson, Ian %A A. Yuen, Darren %A A. Connelly, Kim %A A. Marsden, Philip %A J. Kelly, Darren %A E. Gilbert, Richard %A Advani, Andrew %D 2014 %T CXCR4 and SDF-1 mRNA in sham-operated and subtotally nephrectomized (SNx) rats. %U https://plos.figshare.com/articles/figure/_CXCR4_and_SDF_1_mRNA_in_sham_operated_and_subtotally_nephrectomized_SNx_rats_/963605 %R 10.1371/journal.pone.0092227.g002 %2 https://plos.figshare.com/ndownloader/files/1422411 %K anatomy %K Cardiovascular anatomy %K cell biology %K Cellular structures and organelles %K Extracellular matrix %K Molecular cell biology %K organisms %K animals %K vertebrates %K mammals %K rodents %K rats %K cardiology %K Nephrology %K Chronic kidney disease %K Tubulointerstitial disease %K Vascular medicine %K blood pressure %K hypertension %K Model organisms %K Animal models %K sdf-1 %K mrna %K sham-operated %K subtotally %K nephrectomized %X

CXCR4 expression is increased in the kidneys of SNx rats (A), whereas SDF-1 is reduced (B). The kidneys of SNx rats also demonstrated an upregulation of the pro-fibrotic growth factor, transforming growth factor-β (TGF-β) (C). In cultured NRK-49F renal fibroblasts, recombinant TGF-β downregulated SDF-1 mRNA, with this effect being attenuated by HDAC inhibition with vorinostat (D). *p<0.001 vs. sham, p<0.05 vs. sham, p<0.01 vs. sham, §p<0.001 vs. control, p<0.001 vs. TGF-β.

%I PLOS ONE