MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug
Aline Alfaro
Andrea León
Emanuel Guajardo-Correa
Patricia Reúquen
Francisco Torres
Mario Mery
Rodrigo Segura
Paula A. Zapata
Pedro A. Orihuela
10.1371/journal.pone.0214900
https://plos.figshare.com/articles/dataset/MgO_nanoparticles_coated_with_polyethylene_glycol_as_carrier_for_2-Methoxyestradiol_anticancer_drug/9633908
<div><p>Novel Magnesium Oxide (MgO) nanoparticles (NPs) modified with the polymer polyethylene glycol (PEG) were synthesized as carrier for the anticancer drug 2-Methoxyestradiol (2ME) to improve its clinical application. The functionalized NPs were characterized by Infrared spectroscopy with Fourier transform to elucidate the vibration modes of this conjugate, indicating the formation of the MgO-PEG-2ME nanocomposite. The studies of absorption and liberation determined that MgO-PEG-2ME NPs incorporated 98.51 % of 2ME while liberation of 2ME was constant during 7 days at pH 2, 5 and 7.35. Finally, the MgO-PEG-2ME NPs decreased the viability of the prostate cancer cell line LNCap suggesting that this nanocomposite is suitable as a drug delivery system for anticancer prostate therapy.</p></div>
2019-08-15 17:30:35
MgO-PEG -2ME NPs
drug delivery system
liberation
MgO-PEG -2ME nanocomposite
MgO nanoparticles
anticancer prostate therapy
Infrared spectroscopy
polyethylene glycol
prostate cancer cell line LNCap
2- Methoxyestradiol anticancer drug Novel Magnesium Oxide
functionalized NPs
7 days
carrier
polymer polyethylene glycol
vibration modes