10.1371/journal.pone.0091690
W. David Hill
W.
David Hill
Christiaan de Leeuw
Christiaan
de Leeuw
Gail Davies
Gail
Davies
David Cherry McLachlan Liewald
David
Cherry McLachlan Liewald
Anthony Payton
Anthony
Payton
Leone C. A. Craig
Leone
C. A. Craig
Lawrence J. Whalley
Lawrence
J. Whalley
Mike Horan
Mike
Horan
William Ollier
William
Ollier
John M. Starr
John
M. Starr
Neil Pendleton
Neil
Pendleton
Danielle Posthuma
Danielle
Posthuma
Timothy C. Bates
Timothy
C. Bates
Ian J. Deary
Ian
J. Deary
Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability
Public Library of Science
2014
gene group analyses
cohort
heterotrimeric G protein coding genes
variation
childhood IQ
Cognitive Ability
Functional Gene Group Analysis Indicates
G protein systems
intelligence differences
Heterotrimeric G Proteins
SNP
heterotrimeric G protein genes
time points
nucleotide polymorphisms
2014-03-13 08:41:39
Dataset
https://plos.figshare.com/articles/dataset/_Functional_Gene_Group_Analysis_Indicates_No_Role_for_Heterotrimeric_G_Proteins_in_Cognitive_Ability_/960637
<div><p>Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.</p></div>