10.1371/journal.pone.0091690 W. David Hill W. David Hill Christiaan de Leeuw Christiaan de Leeuw Gail Davies Gail Davies David Cherry McLachlan Liewald David Cherry McLachlan Liewald Anthony Payton Anthony Payton Leone C. A. Craig Leone C. A. Craig Lawrence J. Whalley Lawrence J. Whalley Mike Horan Mike Horan William Ollier William Ollier John M. Starr John M. Starr Neil Pendleton Neil Pendleton Danielle Posthuma Danielle Posthuma Timothy C. Bates Timothy C. Bates Ian J. Deary Ian J. Deary Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability Public Library of Science 2014 gene group analyses cohort heterotrimeric G protein coding genes variation childhood IQ Cognitive Ability Functional Gene Group Analysis Indicates G protein systems intelligence differences Heterotrimeric G Proteins SNP heterotrimeric G protein genes time points nucleotide polymorphisms 2014-03-13 08:41:39 Dataset https://plos.figshare.com/articles/dataset/_Functional_Gene_Group_Analysis_Indicates_No_Role_for_Heterotrimeric_G_Proteins_in_Cognitive_Ability_/960637 <div><p>Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.</p></div>