JNK promotes the activity of mTOR in human CCA cells.
Chunhong Feng
Kai He
Chunyan Zhang
Song Su
Bo Li
Yuxiao Li
Chun-Yan Duan
Shaokun Chen
Run Chen
Youping Liu
Hong Li
Mei Wei
Xianming Xia
Rongyang Dai
10.1371/journal.pone.0090388.g005
https://plos.figshare.com/articles/figure/_JNK_promotes_the_activity_of_mTOR_in_human_CCA_cells_/949287
<p>(A) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated p70S6K in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. Rapamycin (Rap, 20 nM)-treated cholangiocarcinoma cells were used as positive control. (B) After transfected with siJNK for 60 h, phosphorylated p70S6K in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (C) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated mTOR in QBC939, RBE and HCCC-9810 cells was analyzed using western blot. (D) After treated with SP600125 (SP, 20 µM) for indicated time periods, phosphorylated Raptor and phosphorylated 4E-BP1 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.</p>
2014-02-28 04:18:45
biophysics
Protein folding
Molecular cell biology
Signal transduction
Signaling cascades
c-Jun N-terminal kinase signaling cascade
Signaling in selected disciplines
Oncogenic signaling
Cellular stress responses
Gastroenterology and hepatology
Gastrointestinal cancers
oncology
Cancers and neoplasms
Gastrointestinal tumors
mtor
cca