10.1371/journal.pone.0089810.g007
Daniela Farkas
Daniela
Farkas
Donatas Kraskauskas
Donatas
Kraskauskas
Jennifer I. Drake
Jennifer
I. Drake
Aysar A. Alhussaini
Aysar
A. Alhussaini
Vita Kraskauskiene
Vita
Kraskauskiene
Harm J. Bogaard
Harm
J. Bogaard
Carlyne D. Cool
Carlyne
D. Cool
Norbert F. Voelkel
Norbert
F. Voelkel
Laszlo Farkas
Laszlo
Farkas
Proliferation and apoptosis in the lungs of AMD3100-treated SU5416/chronic hypoxia (SuHx) animals.
Public Library of Science
2014
Anatomy and physiology
cardiovascular system
Circulatory physiology
Model organisms
Animal models
rat
Molecular cell biology
Cellular types
Endothelial cells
cardiovascular
Pulmonary vascular diseases
Vascular biology
apoptosis
lungs
amd3100-treated
hypoxia
2014-02-24 03:32:53
Figure
https://plos.figshare.com/articles/figure/_Proliferation_and_apoptosis_in_the_lungs_of_AMD3100_treated_SU5416_chronic_hypoxia_SuHx_animals_/943324
<p>(<b>A</b>) Representative Western blot for proliferating cell nuclear antigen (PCNA) and cleaved caspase-3 in the lung tissue protein lysate of naïve control animals (n = 3), SuHx + vehicle (n = 6) and SuHx + AMD3100 treated rats (n = 6). β-actin was used as loading control. (<b>B-C</b>) Densitometric analysis indicates increased PCNA (B) and cleaved caspase-3 (C) protein levels in the lungs of SuHx + vehicle animals vs. controls, and that AMD3100 treatment significantly reduced PCNA and cleaved caspase-3 protein levels in the lungs of SuHx animals. Densitometric values were normalized vs. β-actin and expressed as n-fold of naïve controls. n = 3 animals per group for controls and n = 6 animals per group for SuHx + vehicle and SuHx + AMD3100 groups. * <i>P</i><0.05 and ** <i>P</i><0.01.</p>