AMD3100 prevented severe pulmonary arterial hypertension (PAH) in the SU5416/chronic hypoxia (SuHx) model.
Daniela Farkas
Donatas Kraskauskas
Jennifer I. Drake
Aysar A. Alhussaini
Vita Kraskauskiene
Harm J. Bogaard
Carlyne D. Cool
Norbert F. Voelkel
Laszlo Farkas
10.1371/journal.pone.0089810.g006
https://plos.figshare.com/articles/figure/_AMD3100_prevented_severe_pulmonary_arterial_hypertension_PAH_in_the_SU5416_chronic_hypoxia_SuHx_model_/943323
<p>(<b>A</b>) Representative von Willebrand Factor (vWF) immunohistochemistry indicates the occlusion of pulmonary arteries (arrows). These images demonstrate that treatment with the CXC chemokine receptor 4 inhibitor AMD3100 only partially prevented the obliteration of pulmonary arteries. Counterstaining: Mayer’s Hematoxylin. Magnification: 100×. Scale bar: 100 µm. (<b>B</b>) Reduced right ventricular systolic pressure (RVSP) and (<b>C</b>) decreased right ventricle (RV)/(left ventricle [LV]+Septum) ratio. (<b>D</b>) Reduced pulmonary arterial muscularization (external diameter [ED] <100 µm) was detected after AMD3100 treatment. (<b>E-F</b>) The degree of obliteration of pulmonary arteries in AMD3100-treated SuHx animals was partially reduced for small (E) (25 µmP<0.05, ** <i>P</i><0.01, *** <i>P</i><0.0001.</p>
2014-02-24 03:32:53
Anatomy and physiology
cardiovascular system
Circulatory physiology
Model organisms
Animal models
rat
Molecular cell biology
Cellular types
Endothelial cells
cardiovascular
Pulmonary vascular diseases
Vascular biology
prevented
pulmonary
arterial
hypertension
hypoxia