K118I/K120P CD28 binds CD80 with high avidity in the absence of TCR signaling.
Mariano Sanchez-Lockhart
Ana V. Rojas
Margaret M. Fettis
Richard Bauserman
Trissha R. Higa
Hongyu Miao
Richard E. Waugh
Jim Miller
10.1371/journal.pone.0089263.g004
https://plos.figshare.com/articles/figure/_K118I_K120P_CD28_binds_CD80_with_high_avidity_in_the_absence_of_TCR_signaling_/943318
<p>Cell frequency adhesion of CD28-deficient, DO11.10 T cells retrovirally transduced with WT CD28-YFP or K118I/K120P CD28-YFP to control beads (None) or beads coated with CD80 in the absence (Unstim) and after (Anti-CD3) stimulation. Cell adhesion data are presented as mean ± SD of the adhesion frequency for individual cells (25 impingements each; n = 6–7 for control beads and 12–14 for CD80-Fc beads; p values for t tests between samples are shown).</p>
2014-02-24 03:32:16
Biochemistry
proteins
Immune system proteins
Protein interactions
protein structure
T-cell receptors
Transmembrane proteins
Biomacromolecule-ligand interactions
Macromolecular assemblies
biophysics
immunology
Immune cells
t cells
Immune response
immunomodulation
Molecular cell biology
Signal transduction
Mechanisms of signal transduction
crosstalk
Membrane receptor signaling
Immunologic receptor signaling
Signaling in cellular processes
Transmembrane signaling
cell adhesion
Computer modeling
Computerized simulations
cd28
binds
cd80
avidity
tcr