10.1371/journal.pone.0089263.g004 Mariano Sanchez-Lockhart Mariano Sanchez-Lockhart Ana V. Rojas Ana V. Rojas Margaret M. Fettis Margaret M. Fettis Richard Bauserman Richard Bauserman Trissha R. Higa Trissha R. Higa Hongyu Miao Hongyu Miao Richard E. Waugh Richard E. Waugh Jim Miller Jim Miller K118I/K120P CD28 binds CD80 with high avidity in the absence of TCR signaling. Public Library of Science 2014 Biochemistry proteins Immune system proteins Protein interactions protein structure T-cell receptors Transmembrane proteins Biomacromolecule-ligand interactions Macromolecular assemblies biophysics immunology Immune cells t cells Immune response immunomodulation Molecular cell biology Signal transduction Mechanisms of signal transduction crosstalk Membrane receptor signaling Immunologic receptor signaling Signaling in cellular processes Transmembrane signaling cell adhesion Computer modeling Computerized simulations cd28 binds cd80 avidity tcr 2014-02-24 03:32:16 Figure https://plos.figshare.com/articles/figure/_K118I_K120P_CD28_binds_CD80_with_high_avidity_in_the_absence_of_TCR_signaling_/943318 <p>Cell frequency adhesion of CD28-deficient, DO11.10 T cells retrovirally transduced with WT CD28-YFP or K118I/K120P CD28-YFP to control beads (None) or beads coated with CD80 in the absence (Unstim) and after (Anti-CD3) stimulation. Cell adhesion data are presented as mean ± SD of the adhesion frequency for individual cells (25 impingements each; n = 6–7 for control beads and 12–14 for CD80-Fc beads; p values for t tests between samples are shown).</p>