Calibration of the deterministic model and the stochastic individual-based model.
Ume L. Abbas
Robert L. Glaubius
Yajun Ding
Gregory Hood
10.1371/journal.pone.0218649.g002
https://plos.figshare.com/articles/figure/Calibration_of_the_deterministic_model_and_the_stochastic_individual-based_model_/8636843
<p>Model calibration to HIV prevalence among (A) women and (B) men by age. Error bars show 95% confidence intervals for data and 95% credible intervals for the IBM model (imperceptible because narrow) and ODE model (posterior) estimates. C: Model calibration to HIV incidence in the ACDSS and comparison to the UNAIDS’ Spectrum model [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0218649#pone.0218649.ref040" target="_blank">40</a>]. D: Model validation against HIV prevalence in KwaZulu-Natal among adults aged 15–24 and 15–49 from the four South African national household surveys [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0218649#pone.0218649.ref007" target="_blank">7</a>]. Abbreviations: ODE, ordinary differential equation; IBM, individual based model; ACDSS, Africa Centre Demographic Surveillance Site; CrI, credible interval.</p>
2019-07-03 20:05:16
first-line antiretroviral therapy
Heterosexual HIV epidemic
HIV drug resistance
alternative first-line regimens
M 184V K 65R
modeling study Background Tenofovir-containing regimens
drug resistance levels
tenofovir-containing first-line ART
NNRTI
CD 4-based ART
Considerable HIV drug resistance
IQR
drug resistance
incident infections
K 65R mutations