%0 Figure %A Jankowski, Marek %A A. Danalache, Bogdan %A Plante, Eric %A Menaouar, Ahmed %A Florian, Maria %A Tan, Ju Jing %A Grygorczyk, Ryszard %A Broderick, Tom L. %A Gutkowska, Jolanta %D 2019 %T Schematic model of human vasopressin receptor (V2R) binding with oxytocin (OT), oxytocin extended form (OT-GKR), and arginine vasopressin (AVP). %U https://plos.figshare.com/articles/figure/Schematic_model_of_human_vasopressin_receptor_V_sub_2_sub_R_binding_with_oxytocin_OT_oxytocin_extended_form_OT-GKR_and_arginine_vasopressin_AVP_/8614559 %R 10.1371/journal.pone.0219205.g005 %2 https://plos.figshare.com/ndownloader/files/15901334 %K OT-GKR %K V 2 %K OT biosynthetic precursor forms %K OT-GK %K CHO cells overexpressing V 2 receptor %K EC %K AVP %K diuresi %K sodium excretion %K OTA %K receptor V 2 %K V 2 R antagonist %K V 2 R %K OT-G %K OTR %X

(A) The front upright view position (side view) of the receptor structure with OT. (B) The top intracellular view (i.e. rotation by 90o out of plane) of OT-GKR inside the OTR binding site.(C) Conformational view of AVP, OT-GKR, and OT and (D) schematic model of human vasopressin V2R binding with AVP, OT-GKR and OT. The amino acid residues in black circles have been proposed as OT docking sites, the red bars represent docking sites of OT-GKR and the green bars represent docking sites of AVP. Amino acid residues are identified by a 1-letter code in Table 1.

%I PLOS ONE