10.1371/journal.pone.0219205.g005 Marek Jankowski Marek Jankowski Bogdan A. Danalache Bogdan A. Danalache Eric Plante Eric Plante Ahmed Menaouar Ahmed Menaouar Maria Florian Maria Florian Ju Jing Tan Ju Jing Tan Ryszard Grygorczyk Ryszard Grygorczyk Tom L. Broderick Tom L. Broderick Jolanta Gutkowska Jolanta Gutkowska Schematic model of human vasopressin receptor (V<sub>2</sub>R) binding with oxytocin (OT), oxytocin extended form (OT-GKR), and arginine vasopressin (AVP). Public Library of Science 2019 OT-GKR V 2 OT biosynthetic precursor forms OT-GK CHO cells overexpressing V 2 receptor EC AVP diuresi sodium excretion OTA receptor V 2 V 2 R antagonist V 2 R OT-G OTR 2019-07-03 17:37:01 Figure https://plos.figshare.com/articles/figure/Schematic_model_of_human_vasopressin_receptor_V_sub_2_sub_R_binding_with_oxytocin_OT_oxytocin_extended_form_OT-GKR_and_arginine_vasopressin_AVP_/8614559 <p>(A) The front upright view position (side view) of the receptor structure with OT. (B) The top intracellular view (i.e. rotation by 90<sup>o</sup> out of plane) of OT-GKR inside the OTR binding site.(C) Conformational view of AVP, OT-GKR, and OT and (D) schematic model of human vasopressin V<sub>2</sub>R binding with AVP, OT-GKR and OT. The amino acid residues in black circles have been proposed as OT docking sites, the red bars represent docking sites of OT-GKR and the green bars represent docking sites of AVP. Amino acid residues are identified by a 1-letter code in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0219205#pone.0219205.t001" target="_blank">Table 1</a>.</p>