10.1371/journal.pone.0219205.g005
Marek Jankowski
Marek
Jankowski
Bogdan A. Danalache
Bogdan
A. Danalache
Eric Plante
Eric
Plante
Ahmed Menaouar
Ahmed
Menaouar
Maria Florian
Maria
Florian
Ju Jing Tan
Ju Jing
Tan
Ryszard Grygorczyk
Ryszard
Grygorczyk
Tom L. Broderick
Tom L.
Broderick
Jolanta Gutkowska
Jolanta
Gutkowska
Schematic model of human vasopressin receptor (V<sub>2</sub>R) binding with oxytocin (OT), oxytocin extended form (OT-GKR), and arginine vasopressin (AVP).
Public Library of Science
2019
OT-GKR
V 2
OT biosynthetic precursor forms
OT-GK
CHO cells overexpressing V 2 receptor
EC
AVP
diuresi
sodium excretion
OTA
receptor V 2
V 2 R antagonist
V 2 R
OT-G
OTR
2019-07-03 17:37:01
Figure
https://plos.figshare.com/articles/figure/Schematic_model_of_human_vasopressin_receptor_V_sub_2_sub_R_binding_with_oxytocin_OT_oxytocin_extended_form_OT-GKR_and_arginine_vasopressin_AVP_/8614559
<p>(A) The front upright view position (side view) of the receptor structure with OT. (B) The top intracellular view (i.e. rotation by 90<sup>o</sup> out of plane) of OT-GKR inside the OTR binding site.(C) Conformational view of AVP, OT-GKR, and OT and (D) schematic model of human vasopressin V<sub>2</sub>R binding with AVP, OT-GKR and OT. The amino acid residues in black circles have been proposed as OT docking sites, the red bars represent docking sites of OT-GKR and the green bars represent docking sites of AVP. Amino acid residues are identified by a 1-letter code in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0219205#pone.0219205.t001" target="_blank">Table 1</a>.</p>