%0 Figure %A Rodrigues de Melo, Nadja %A Abdrahman, Ahmed %A Greig, Carolyn %A Mukherjee, Krishnendu %A Thornton, Catherine %A A. Ratcliffe, Norman %A Vilcinskas, Andreas %A M. Butt, Tariq %D 2013 %T Gene expression comparison between C. albicans alone and drug-treated groups in Galleria mellonella. %U https://plos.figshare.com/articles/figure/_Gene_expression_comparison_between_C_albicans_alone_and_drug_treated_groups_in_Galleria_mellonella_/853259 %R 10.1371/journal.pone.0078905.g008 %2 https://plos.figshare.com/ndownloader/files/1284018 %K drug-treated %K groups %X

Gene expression comparing C. albicans infected larvae group with and without antifungals. Expression of 17 gene transcripts in response to C. albicans and antifungal drugs 24 h post treatment. The value in each heat-map cell corresponds to the mean gene expression fold change relative to the uninjected larvae control (basal expression). To visualize the change in the gene expression a color gradient was used. The color gradients correspond to 3 different levels of gene expression relative to CA group. A light color represents low gene expression i.e.0–25% of that expressed by C. albicans alone; intermediate color to moderate gene expression i.e. 25%–50% of C. albicans alone; dark color to high gene expression, above 50% of C. albicans alone. The effect of MYR during Candida pathogenesis (MYR+CA group) in the Galleria larvae in comparison with CA group, showed a significant increase (*p<0.001) in the level of gene expression of 3 antimicrobial peptides GLIO, GVL and TSF, toll receptor 18W and stress related gene C1. On the other hand this treatment also caused a significant decrease of gene expression of IMPI, C5 (*p<0.001), C6 and C7 (**p<0.05). Abbreviations listed in Figure 7.

%I PLOS ONE