Model of sIL-2R elevation in B-cell lymphomas.
Noriaki Yoshida
Miyo Oda
Yoshiaki Kuroda
Yuta Katayama
Yoshiko Okikawa
Taro Masunari
Megumu Fujiwara
Takashi Nishisaka
Naomi Sasaki
Yoshito Sadahira
Keichiro Mihara
Hideki Asaoku
Hirotaka Matsui
Masao Seto
Akiro Kimura
Koji Arihiro
Akira Sakai
10.1371/journal.pone.0078730.g006
https://plos.figshare.com/articles/figure/_Model_of_sIL_2R_elevation_in_B_cell_lymphomas_/848844
<p>MMP-9 released from tumor associated macrophages (especially CD68-positive) cleaves the IL-2R α chain on bystander T-cells and B-lymphoma cells, if they express CD25 (IL-2Rα). This mechanism may be involved in elevation of sIL-2R levels in patients with B-cell lymphomas.</p>
2013-11-13 02:56:27
sil-2r
elevation
B-cell