10.1371/journal.pone.0077944
Wai Lim Ku
Wai
Lim Ku
Michelle Girvan
Michelle
Girvan
Guo-Cheng Yuan
Guo-Cheng
Yuan
Francesco Sorrentino
Francesco
Sorrentino
Edward Ott
Edward
Ott
Modeling the Dynamics of Bivalent Histone Modifications
Public Library of Science
2013
bivalent
histone
2013-11-01 03:13:43
Dataset
https://plos.figshare.com/articles/dataset/_Modeling_the_Dynamics_of_Bivalent_Histone_Modifications_/840374
<div><p>Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have “bivalent domains” in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states.</p></div>