HSV-1 infects human NK cells.
Tessa Mollie Campbell
Brian Patrick McSharry
Megan Steain
Tiffany Ann Russell
David Carl Tscharke
Jarrod John Kennedy
Barry Slobedman
Allison Abendroth
10.1371/journal.ppat.1007784.g005
https://plos.figshare.com/articles/figure/HSV-1_infects_human_NK_cells_/8272889
<p>(A) PBMCs were cultured with mock infected inoculum or inoculum infected with HSV-1 expressing GFP under different viral promoters (ICP47, ICP6 or gB as specified) for 1 day. Infection of NK cells (viable CD3<sup>–</sup>CD56<sup>+</sup> cells) was determined by flow cytometry detection of GFP. (B) Frequency of NK cell infection with HSV-1 GFP-pICP47 performed as in (A), for seven donors. Symbols represent individual donors, and bar indicates mean.</p>
2019-06-13 17:53:13
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multiparameter flow cytometry
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IFN
NK cells
varicella zoster virus
NK cell surface receptor phenotype
herpes simplex virus type 1
VZV potently impairs
target cell stimulation
alphaherpesviruses Natural killer
NK cell function
TNF