HSV-1 infects human NK cells. Tessa Mollie Campbell Brian Patrick McSharry Megan Steain Tiffany Ann Russell David Carl Tscharke Jarrod John Kennedy Barry Slobedman Allison Abendroth 10.1371/journal.ppat.1007784.g005 https://plos.figshare.com/articles/figure/HSV-1_infects_human_NK_cells_/8272889 <p>(A) PBMCs were cultured with mock infected inoculum or inoculum infected with HSV-1 expressing GFP under different viral promoters (ICP47, ICP6 or gB as specified) for 1 day. Infection of NK cells (viable CD3<sup>–</sup>CD56<sup>+</sup> cells) was determined by flow cytometry detection of GFP. (B) Frequency of NK cell infection with HSV-1 GFP-pICP47 performed as in (A), for seven donors. Symbols represent individual donors, and bar indicates mean.</p> 2019-06-13 17:53:13 VZV paralyses NK cells multiparameter flow cytometry HSV IFN NK cells varicella zoster virus NK cell surface receptor phenotype herpes simplex virus type 1 VZV potently impairs target cell stimulation alphaherpesviruses Natural killer NK cell function TNF