%0 Figure %A Jannaway, Melanie %A Yang, Xiaoyuan %A Meegan, Jamie E. %A Coleman, Danielle C. %A Y. Yuan, Sarah %D 2019 %T Syndecan family is expressed in microvasculature of human lung. %U https://plos.figshare.com/articles/figure/Syndecan_family_is_expressed_in_microvasculature_of_human_lung_/8132960 %R 10.1371/journal.pone.0214737.g002 %2 https://plos.figshare.com/ndownloader/files/15160247 %K thrombin receptor PAR 1. %K barrier integrity %K disease states %K barrier function %K syndecan -3 ectodomain fragments %K Syndecan proteins %K plasma protein leakage %K glycocalyx %K Rho kinase inhibitor %K ELISA %K VE-cadherin-based adherens junction disorganization %K albumin-bound Evans %K transmission electron microscopy %K syndecan subtypes %K F-actin stress fibers %K mouse lung %K intercellular gaps %K transmigrating cells %K barrier dysfunction Objective %K paracellular hyperpermeability %K thrombotic disease states %K cleavage products %K paracellular permeability %K blot analysis %K lung microvasculature %X

Sections of agarose-inflated human lung were stained for each of the four syndecan ectodomains and the endothelial cell marker, PECAM-1. Confocal images demonstrate co-localization of PECAM-1 with all four syndecan ectodomain proteins, indicating expression throughout the pulmonary microvasculature. Scale bars: 100 μm.

%I PLOS ONE