10.1371/journal.pone.0214737.g002 Melanie Jannaway Melanie Jannaway Xiaoyuan Yang Xiaoyuan Yang Jamie E. Meegan Jamie E. Meegan Danielle C. Coleman Danielle C. Coleman Sarah Y. Yuan Sarah Y. Yuan Syndecan family is expressed in microvasculature of human lung. Public Library of Science 2019 thrombin receptor PAR 1. barrier integrity disease states barrier function syndecan -3 ectodomain fragments Syndecan proteins plasma protein leakage glycocalyx Rho kinase inhibitor ELISA VE-cadherin-based adherens junction disorganization albumin-bound Evans transmission electron microscopy syndecan subtypes F-actin stress fibers mouse lung intercellular gaps transmigrating cells barrier dysfunction Objective paracellular hyperpermeability thrombotic disease states cleavage products paracellular permeability blot analysis lung microvasculature 2019-05-15 17:25:17 Figure https://plos.figshare.com/articles/figure/Syndecan_family_is_expressed_in_microvasculature_of_human_lung_/8132960 <p>Sections of agarose-inflated human lung were stained for each of the four syndecan ectodomains and the endothelial cell marker, PECAM-1. Confocal images demonstrate co-localization of PECAM-1 with all four syndecan ectodomain proteins, indicating expression throughout the pulmonary microvasculature. Scale bars: 100 μm.</p>