10.1371/journal.pone.0074335.g001
Andreas Raue
Andreas
Raue
Marcel Schilling
Marcel
Schilling
Julie Bachmann
Julie
Bachmann
Andrew Matteson
Andrew
Matteson
Max Schelke
Max
Schelke
Daniel Kaschek
Daniel
Kaschek
Sabine Hug
Sabine
Hug
Clemens Kreutz
Clemens
Kreutz
Brian D. Harms
Brian
D. Harms
Fabian J. Theis
Fabian J.
Theis
Ursula Klingmüller
Ursula
Klingmüller
Jens Timmer
Jens
Timmer
Quantitative dynamic models describing erythropoetin signaling used as examples.
Public Library of Science
2013
describing
erythropoetin
2013-09-30 02:15:45
Figure
https://plos.figshare.com/articles/figure/_Quantitative_dynamic_models_describing_erythropoetin_signaling_used_as_examples_/811089
<p>The hormone erythropoietin (Epo) is the key regulator of erythropoiesis, the production of red blood cells. (<b>a</b>) Epo receptor model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074335#pone.0074335-Becker1" target="_blank">[2]</a>. The model describes the interaction and the trafficking of the hormone and of its membrane receptor (EpoR). The active complex Epo_EpoR can be internalized (Epo_EpoR) and is either recycled back to the cell membrane or is degraded (dEpo, dEpo). (<b>b</b>) Model of Epo induced JAK2/STAT5 signaling <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074335#pone.0074335-Bachmann1" target="_blank">[7]</a>. In erythroid progenitor cells (CFU-E), the hormone Epo induces activation of the tyrosine kinase Janus kinase 2 (JAK2). Subsequently, the signal transducer and activator of transcription 5 protein (STAT5) is activated and shuttles to the nucleus where it induces target gene expression. Two of the target genes encode for the negative feedback regulators suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible SH2-containing protein (CIS).</p>