10.1371/journal.pone.0074335.g001 Andreas Raue Andreas Raue Marcel Schilling Marcel Schilling Julie Bachmann Julie Bachmann Andrew Matteson Andrew Matteson Max Schelke Max Schelke Daniel Kaschek Daniel Kaschek Sabine Hug Sabine Hug Clemens Kreutz Clemens Kreutz Brian D. Harms Brian D. Harms Fabian J. Theis Fabian J. Theis Ursula Klingmüller Ursula Klingmüller Jens Timmer Jens Timmer Quantitative dynamic models describing erythropoetin signaling used as examples. Public Library of Science 2013 describing erythropoetin 2013-09-30 02:15:45 Figure https://plos.figshare.com/articles/figure/_Quantitative_dynamic_models_describing_erythropoetin_signaling_used_as_examples_/811089 <p>The hormone erythropoietin (Epo) is the key regulator of erythropoiesis, the production of red blood cells. (<b>a</b>) Epo receptor model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074335#pone.0074335-Becker1" target="_blank">[2]</a>. The model describes the interaction and the trafficking of the hormone and of its membrane receptor (EpoR). The active complex Epo_EpoR can be internalized (Epo_EpoR) and is either recycled back to the cell membrane or is degraded (dEpo, dEpo). (<b>b</b>) Model of Epo induced JAK2/STAT5 signaling <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074335#pone.0074335-Bachmann1" target="_blank">[7]</a>. In erythroid progenitor cells (CFU-E), the hormone Epo induces activation of the tyrosine kinase Janus kinase 2 (JAK2). Subsequently, the signal transducer and activator of transcription 5 protein (STAT5) is activated and shuttles to the nucleus where it induces target gene expression. Two of the target genes encode for the negative feedback regulators suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible SH2-containing protein (CIS).</p>