Programmed cell death mutants share differentially regulated genes. E. JudyMeredith NakamuraAyumi HuangAnne GrantHarli McCurdyHelen F. WeiberthKurt GaoFuying CoppolaGiovanni KenyonCynthia W. KaoAimee 2013 <p>(A) Venn diagram of differentially regulated genes in day 1 adult wild-type (N2) animals versus <i>pgrn-1(tm985)</i>, <i>ced-3(n717)</i> or <i>ced-1(e1735)</i> mutants. Significance cut-off was an FDR of <0.05. The numbers in black represent the total number of overlapping genes, with direction of change (up-regulated = red, down-regulated = green) indicated below. The significance of the overlaps between the mutant strains was calculated using Fisher's exact test. See the Excel file (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003714#pgen.1003714.s017" target="_blank">Table S5</a>) for gene list. *p value<2.2×10<sup>−16</sup>. (B) Heat map depicting the fold changes of gene expression in <i>pgrn-1(tm985), ced-3(n717)</i> and <i>ced-1(e1735)</i> mutants compared to N2 wild-type animals for each of four biological replicates.</p>