Estimated breath of guinea pig sera. Cheng Cheng Kai Xu Rui Kong Gwo-Yu Chuang Angela R. Corrigan Hui Geng Kurt R. Hill Alexander J. Jafari Sijy O’Dell Li Ou Reda Rawi Ariana P. Rowshan Edward K. Sarfo Mallika Sastry Kevin O. Saunders Stephen D. Schmidt Shuishu Wang Winston Wu Baoshan Zhang Nicole A. Doria-Rose Barton F. Haynes Diana G. Scorpio Lawrence Shapiro John R. Mascola Peter D. Kwong 10.1371/journal.pone.0215163.g006 https://plos.figshare.com/articles/figure/Estimated_breath_of_guinea_pig_sera_/8008451 <p><b>A</b>. FP-directed neutralizing antibodies cluster together with similar neutralization fingerprints [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.ref022" target="_blank">22</a>] as assessed on 208 strains. Vaccine-elicited antibodies are shown in italics with FP-directed antibodies highlighted in red. <b>B</b>. Correlation of breadths for FP-directed antibodies on 60-strain panel versus 208-strain panel. 95% CI of slope ranges from 0.4604 to 0.6112. <b>C</b>. Guinea pig serum neutralization breadth on 60-strain panel and predicted breadth on 208-strain panel based on correlation in B, with ID<sub>50</sub> shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.s004" target="_blank">S4 Table</a>. Predicted breadths are shown with 95% CI in parentheses. Sufficient sera were available to allow neutralization characterization with only the three animals shown. <b>D</b>. Neutralization fingerprints cluster together [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.ref022" target="_blank">22</a>] for guinea pig sera (CGP701-1, CGP701-2, CGP701-5, highlighted in blue) and FP-directed neutralizing antibodies (highlighted in red) when assessed on a 60-strain panel. Notably, the vaccine-elicited antibodies and sera (shown in italics) cluster as a separate subgroup.</p> 2019-04-17 17:40:43 trimer-boosted neutralizing responses cross-clade HIV-neutralizing responses 19 wild-type strains founder clade C strain heterologous Env trimer BG 505 strain ID guinea pigs CH 505 trimer heterologous neutralizing response fusion peptide 19- strain panel Env-trimer immunizations cross-reactive serum neutralization autologous response FP-directed neutralizing responses cross-clade neutralizing responses