Estimated breath of guinea pig sera.
Cheng Cheng
Kai Xu
Rui Kong
Gwo-Yu Chuang
Angela R. Corrigan
Hui Geng
Kurt R. Hill
Alexander J. Jafari
Sijy O’Dell
Li Ou
Reda Rawi
Ariana P. Rowshan
Edward K. Sarfo
Mallika Sastry
Kevin O. Saunders
Stephen D. Schmidt
Shuishu Wang
Winston Wu
Baoshan Zhang
Nicole A. Doria-Rose
Barton F. Haynes
Diana G. Scorpio
Lawrence Shapiro
John R. Mascola
Peter D. Kwong
10.1371/journal.pone.0215163.g006
https://plos.figshare.com/articles/figure/Estimated_breath_of_guinea_pig_sera_/8008451
<p><b>A</b>. FP-directed neutralizing antibodies cluster together with similar neutralization fingerprints [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.ref022" target="_blank">22</a>] as assessed on 208 strains. Vaccine-elicited antibodies are shown in italics with FP-directed antibodies highlighted in red. <b>B</b>. Correlation of breadths for FP-directed antibodies on 60-strain panel versus 208-strain panel. 95% CI of slope ranges from 0.4604 to 0.6112. <b>C</b>. Guinea pig serum neutralization breadth on 60-strain panel and predicted breadth on 208-strain panel based on correlation in B, with ID<sub>50</sub> shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.s004" target="_blank">S4 Table</a>. Predicted breadths are shown with 95% CI in parentheses. Sufficient sera were available to allow neutralization characterization with only the three animals shown. <b>D</b>. Neutralization fingerprints cluster together [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0215163#pone.0215163.ref022" target="_blank">22</a>] for guinea pig sera (CGP701-1, CGP701-2, CGP701-5, highlighted in blue) and FP-directed neutralizing antibodies (highlighted in red) when assessed on a 60-strain panel. Notably, the vaccine-elicited antibodies and sera (shown in italics) cluster as a separate subgroup.</p>
2019-04-17 17:40:43
trimer-boosted neutralizing responses
cross-clade HIV-neutralizing responses
19 wild-type strains
founder clade C strain
heterologous Env trimer
BG 505 strain
ID
guinea pigs
CH 505 trimer
heterologous neutralizing response
fusion peptide
19- strain panel
Env-trimer immunizations
cross-reactive serum neutralization
autologous response
FP-directed neutralizing responses
cross-clade neutralizing responses