%0 Figure %A L. Ronchi, Cristina %A Sbiera, Silviu %A Leich, Ellen %A Henzel, Katharina %A Rosenwald, Andreas %A Allolio, Bruno %A Fassnacht, Martin %D 2013 %T Pathway analysis for genes frequently affected by copy number alterations in both adenomas and carcinomas. %U https://plos.figshare.com/articles/figure/_Pathway_analysis_for_genes_frequently_affected_by_copy_number_alterations_in_both_adenomas_and_carcinomas_/800146 %R 10.1371/journal.pone.0073959.g006 %2 https://plos.figshare.com/ndownloader/files/1205366 %K genes %K affected %K alterations %K adenomas %X

A) List of the most significantly altered pathways according to the GeneGo analysis (Meta Core Analytical suite) including all the genes (n=696 annotated genes) with copy number alterations observed in at least 4 samples (recurrent CNA) in both adenomas and carcinomas. The P values are expresses as logarithmic scale. B) Graphical representation of the Notch signaling pathway map (gene ontology enrichment, P=2.913e-4).

C) Graphical representation of the WNT5 signaling pathway (gene ontology enrichment, P=3.256e-3).

Genes with gains are underlined in red and genes with losses in blue. Detailed legend is available at http://pathwaymaps.com/pdf/MC_legend.pdf.

%I PLOS ONE