%0 Figure %A Parashar, Deepti %A S. Paingankar, Mandar %A Kumar, Satyendra %A D. Gokhale, Mangesh %A B. Sudeep, A. %A B. Shinde, Sapana %A A. Arankalle, V. %D 2013 %T The reduction in CHIKV copies/ml serum after injection with siRNA Chik-1 and Chik-5 in Swiss albino mice infected with CHIKV. %U https://plos.figshare.com/articles/figure/_The_reduction_in_CHIKV_copies_ml_serum_after_injection_with_siRNA_Chik_1_and_Chik_5_in_Swiss_albino_mice_infected_with_CHIKV_/790503 %R 10.1371/journal.pntd.0002405.g007 %2 https://plos.figshare.com/ndownloader/files/1193396 %K microbiology %K chikv %K serum %K injection %K sirna %K chik-1 %K chik-5 %K swiss %K albino %K mice %K infected %X

Swiss albino mice were infected with CHIKV i.v. (1×106 PFU CHKV; 100 µl of 107pfu/ml). After 72 h of p.i. mice were inoculated i.v. with A) ncsiRNA 1 mg/kg body weight B) 1 mg/kg body weight Chik-1 (n = 3), C) 1 mg/kg body weight Chik-5 (n = 3) and D) Comb-siRNA (n = 3) 1 mg/kg body weight each. At indicated time after injection of siRNA blood was collected from eye and RNA was isolated from serum. CHIKV E3 RNA was quantitated using real time RT-PCR. Values are given as LOG10 RNA copies/ml serum. Significance ANOVA, Dunnett's test: *p<0.05; **p<0.01.

%I PLOS Neglected Tropical Diseases