H. Nagy, Lauren Grishina, Irina Macal, Monica A. Hirao, Lauren K. Hu, William Sankaran-Walters, Sumathi A. Gaulke, Christopher Pollard, Richard Brown, Jennifer Suni, Maria Baumler, Andreas J. Ghanekar, Smita Marco, Maria L. Dandekar, Satya Enhanced APC inflammatory response to commensal lactobacilli signals predominantly through p38-MAPK. <p>(<b>A</b>) Representative flow cytometry plot and frequencies of APCs from HIV-infected patients producing proinflammatory cytokines IL-6, IL-12/IL-23p40, and TNFα in response to (<b>B</b>) <i>L. plantarum</i> WCFS1 (n = 16), (<b>C</b>) <i>L. gasseri</i> 1SL4 (n = 12), and (<b>D</b>) <i>L. casei</i> BL23 (n = 11) with or without BIRB796 pretreatment. (<b>E</b>) Relative expression of MKP-1 in unstimulated and bacterial stimulated APCs as determined by real-time PCR (HIV− n = 3–9, HIV+ n = 5–16). Bar graphs represent mean +/− SEM. P values determined using paired t or Mann Whitney U test (*P<0.05, **P<0.01, ***P<0.001).</p> immunology;Immune cells;Antigen-presenting cells;Immune system;cytokines;microbiology;immunity;Immune activation;inflammation;Innate immunity;Host-pathogen interaction;Molecular cell biology;Signal transduction;Signaling in selected disciplines;Immunological signaling;Infectious diseases;Viral diseases;hiv;apc;inflammatory;commensal;lactobacilli;signals;predominantly 2013-08-30
    https://plos.figshare.com/articles/figure/_Enhanced_APC_inflammatory_response_to_commensal_lactobacilli_signals_predominantly_through_p38_MAPK_/785646
10.1371/journal.pone.0072789.g005