10.1371/journal.pone.0072790.g007
Guihua Liu
Guihua
Liu
Xiangzhou Sun
Xiangzhou
Sun
Jun Bian
Jun
Bian
Rongpei Wu
Rongpei
Wu
Xuan Guan
Xuan
Guan
Bin Ouyang
Bin
Ouyang
Yanping Huang
Yanping
Huang
Haipeng Xiao
Haipeng
Xiao
Daosheng Luo
Daosheng
Luo
Anthony Atala
Anthony
Atala
Yuanyuan Zhang
Yuanyuan
Zhang
Chunhua Deng
Chunhua
Deng
ADSCs-VEGF increased cavernous smooth muscle content in STZ-induced diabetic rats.
Public Library of Science
2013
Computational biology
Molecular genetics
gene expression
developmental biology
stem cells
mesenchymal stem cells
genetics
Model organisms
Animal models
rat
Molecular cell biology
Cellular types
Clinical research design
Animal models of disease
Endocrinology
Diabetic endocrinology
Diabetes mellitus type 1
urology
Sexual dysfunction
cavernous
stz-induced
diabetic
2013-08-30 02:07:09
Figure
https://plos.figshare.com/articles/figure/_ADSCs_VEGF_increased_cavernous_smooth_muscle_content_in_STZ_induced_diabetic_rats_/785600
<p>Masson’s trichrome staining (A) and semi-quantitative evaluation (B) of smooth muscle/collagen ratio in the cavernous tissue showed this ratio was lower in PBS-treated diabetic rats than age-matched normal rats and was improved by ADSCs or lentivirus-VEGF or ADSCs-VEGF treatment. Scale bar = 50 µm; *<i>p</i><0.05, **<i>p</i><0.01. C: Immunofluorescent staining of cavernous tissue was performed with α-actin and smoothelin in age-matched control rats and STZ-induced DED rats treated with PBS or ADSCs or lentivirus-VEGF or ADSCs-VEGF. Scale bar = 50 µm. D: Representative Western blot for a-actin and smoothelin in normal rats and STZ-induced DED rats after 1 weeks and 4 weeks treatment with PBS, ADSCs, lentivirus-VEGF, or ADSCs-VEGF. E: Quantitative analysis of immunoblotting using Quantity One® software. *<i>p</i><0.05, **<i>p</i><0.01.</p>