%0 Figure %A Sun, Ryan %A Hui, Shirley %A D. Bader, Gary %A Lin, Xihong %A Kraft, Peter %D 2019 %T Difference between observed and expected number of significant pathways arising from Gene Ontology Biological Process categories. %U https://plos.figshare.com/articles/figure/Difference_between_observed_and_expected_number_of_significant_pathways_arising_from_Gene_Ontology_Biological_Process_categories_/7853183 %R 10.1371/journal.pgen.1007530.g006 %2 https://plos.figshare.com/ndownloader/files/14623667 %K GSA %K Single Nucleotide Polymorphisms %K breast cancer pathway analysis %K SNP %K Generalized Berk-Jones statistic %K set-based testing settings %K Genome-Wide Association Studies %K GBJ step-down inference technique %K FGFR %K breast cancer GWAS %K gene %K summary statistics %X

For a given phenotype, expected number is equal to the percentage of all tested pathways belonging to a category multiplied by the total number of significant pathways. The difference between observed and expected counts is expressed as a percentage of the expected number. A value greater than 0 indicates there are more significant pathways in a category than expected. A value less than 0 indicates there are less significant pathways than expected. A number of familiar themes are present, including the high number of significant height pathways related to growth and the high number of significant schizophrenia pathways related to the immune system.

%I PLOS Genetics