10.1371/journal.pcbi.1006402.g007 Herbert Sizek Herbert Sizek Andrew Hamel Andrew Hamel Dávid Deritei Dávid Deritei Sarah Campbell Sarah Campbell Erzsébet Ravasz Regan Erzsébet Ravasz Regan The strength of <i>Plk1</i> inhibition sets the relative prominence of cell cycle failure modes. Public Library of Science 2019 Boolean model Plk 1 inhibition PI 3K subunits cell fate decisions PI 3K oscillations Polo-like kinase 1 cell cycle entry oncogenic PI 3K AKT 1 phase Plk 1 genome duplication cytokinesis failure offer testable predictions AKT 1 PI 3K G 2 arrest cell cycle cell cycle progression cell survival 2019-03-15 17:38:31 Figure https://plos.figshare.com/articles/figure/The_strength_of_i_Plk1_i_inhibition_sets_the_relative_prominence_of_cell_cycle_failure_modes_/7853069 <p>Stacked bar charts showing the relative occurrence of normal cell cycle completion (<i>mustard</i>), G2 → G1 reset followed by genome duplication (<i>purple</i>), aberrant mitosis followed by genome duplication (<i>turquoise</i>), failed cytokinesis followed by genome duplication (<i>blue</i>) and apoptosis (<i>dark red</i>) relative to the rate of cell cycle in wild-type cells (<i>black dashed line</i>) at growth factor exposure of 40%, 60% and 80% in <i>Plk1</i>-deficient cells using synchronous (<i>top</i>) and biased asynchronous update (<i>bottom</i>).</p>