10.1371/journal.pcbi.1006402.g007
Herbert Sizek
Herbert
Sizek
Andrew Hamel
Andrew
Hamel
Dávid Deritei
Dávid
Deritei
Sarah Campbell
Sarah
Campbell
Erzsébet Ravasz Regan
Erzsébet Ravasz
Regan
The strength of <i>Plk1</i> inhibition sets the relative prominence of cell cycle failure modes.
Public Library of Science
2019
Boolean model
Plk 1 inhibition
PI 3K subunits
cell fate decisions
PI 3K oscillations
Polo-like kinase 1
cell cycle entry
oncogenic PI 3K
AKT 1 phase
Plk 1
genome duplication
cytokinesis failure
offer testable predictions
AKT 1
PI 3K
G 2 arrest
cell cycle
cell cycle progression
cell survival
2019-03-15 17:38:31
Figure
https://plos.figshare.com/articles/figure/The_strength_of_i_Plk1_i_inhibition_sets_the_relative_prominence_of_cell_cycle_failure_modes_/7853069
<p>Stacked bar charts showing the relative occurrence of normal cell cycle completion (<i>mustard</i>), G2 → G1 reset followed by genome duplication (<i>purple</i>), aberrant mitosis followed by genome duplication (<i>turquoise</i>), failed cytokinesis followed by genome duplication (<i>blue</i>) and apoptosis (<i>dark red</i>) relative to the rate of cell cycle in wild-type cells (<i>black dashed line</i>) at growth factor exposure of 40%, 60% and 80% in <i>Plk1</i>-deficient cells using synchronous (<i>top</i>) and biased asynchronous update (<i>bottom</i>).</p>