Xie, Yuquan Li, Minghui Wang, Xinggang Zhang, Xian Peng, Tianqing Yang, Yingzhen Zou, Yunzeng Ge, Junbo Chen, Haozhu Chen, Ruizhen Cardiac remodeling reverses following treatment with Ad-IL-17AR:Fc in chronic viral myocarditis in mice. <p>Groups of BALB/c mice were infused with Ad:null, Ad-IL-17AR:Fc or PBS. (<i>A</i>) Survival curves for mice after CVB3 infection. The mice in each group (n = 20) were monitored for up to 90 days after the intraperitoneal administration of CVB3. (<i>B</i>) Heart weight to body weight ratio (HW/BW) measured in five mice from the different groups (g/g). (<i>C</i>) Representative images of the heart from three mice (×50) and transthoracic M-mode tracings indicating the measurements. (<i>D</i>) The echocardiographic measurements are shown as the mean ± S.E.M. from five mice. LVIDS, Left ventricle internal dimension at end-systole; LVIDD, Left ventricle internal dimension at end-diastole; EF, Left ventricle ejection fraction; LVFS, Left ventricle fraction shortening. The values are expressed as the mean ± S.E.M. of five mice from each group. **<i>p</i><0.01, *<i>p</i><0.05 vs control.</p> immunology;Immune cells;t cells;Immune system;cytokines;microbiology;Vector biology;Viral vectors;Model organisms;Animal models;mouse;Molecular cell biology;Extracellular matrix;cardiovascular;cardiomyopathies;Interventional cardiology;Clinical immunology;Infectious diseases;Viral diseases;toxicology;Immunotoxicology;remodeling;reverses;viral;myocarditis 2013-08-20
    https://plos.figshare.com/articles/figure/_Cardiac_remodeling_reverses_following_treatment_with_Ad_IL_17AR_Fc_in_chronic_viral_myocarditis_in_mice_/777055
10.1371/journal.pone.0072158.g003