%0 Figure %A Xie, Yuquan %A Li, Minghui %A Wang, Xinggang %A Zhang, Xian %A Peng, Tianqing %A Yang, Yingzhen %A Zou, Yunzeng %A Ge, Junbo %A Chen, Haozhu %A Chen, Ruizhen %D 2013 %T Cardiac remodeling reverses following treatment with Ad-IL-17AR:Fc in chronic viral myocarditis in mice. %U https://plos.figshare.com/articles/figure/_Cardiac_remodeling_reverses_following_treatment_with_Ad_IL_17AR_Fc_in_chronic_viral_myocarditis_in_mice_/777055 %R 10.1371/journal.pone.0072158.g003 %2 https://plos.figshare.com/ndownloader/files/1175802 %K immunology %K Immune cells %K t cells %K Immune system %K cytokines %K microbiology %K Vector biology %K Viral vectors %K Model organisms %K Animal models %K mouse %K Molecular cell biology %K Extracellular matrix %K cardiovascular %K cardiomyopathies %K Interventional cardiology %K Clinical immunology %K Infectious diseases %K Viral diseases %K toxicology %K Immunotoxicology %K remodeling %K reverses %K viral %K myocarditis %X

Groups of BALB/c mice were infused with Ad:null, Ad-IL-17AR:Fc or PBS. (A) Survival curves for mice after CVB3 infection. The mice in each group (n = 20) were monitored for up to 90 days after the intraperitoneal administration of CVB3. (B) Heart weight to body weight ratio (HW/BW) measured in five mice from the different groups (g/g). (C) Representative images of the heart from three mice (×50) and transthoracic M-mode tracings indicating the measurements. (D) The echocardiographic measurements are shown as the mean ± S.E.M. from five mice. LVIDS, Left ventricle internal dimension at end-systole; LVIDD, Left ventricle internal dimension at end-diastole; EF, Left ventricle ejection fraction; LVFS, Left ventricle fraction shortening. The values are expressed as the mean ± S.E.M. of five mice from each group. **p<0.01, *p<0.05 vs control.

%I PLOS ONE