%0 Figure %A Varela, Paloma Fernández %A Velours, Christophe %A Aumont-Niçaise, Magali %A Pineau, Blandine %A Legrand, Pierre %A Poquet, Isabelle %D 2019 %T Structure of holo-ZitRMG dimer. %U https://plos.figshare.com/articles/figure/Structure_of_holo-ZitR_sub_MG_sub_dimer_/7708856 %R 10.1371/journal.pone.0210123.g002 %2 https://plos.figshare.com/ndownloader/files/14344529 %K helix-turn-helix DNA-binding domain %K ZitR %K MarR superfamily %K Multi Angle Light Scattering %K bacteria %K Size Exclusion Chromatography-coupled %K Lactococcus lactis species %K Ferric uptake regulator %K MG %K repressor %K Isothermal Titration Calorimetry show %K Zn %K palindromic operator sites %K Streptococcaceae group use %K MarR metallo-regulator subgroup %X

(A) Overall structure. Protomers A and B of ZitRMG dimer, represented in ribbon, are colored in dark and light green respectively, and their N- and C-terminus are indicated. Zn(II) atoms are shown as small green spheres. Helices and strands are labelled. The dimerization interface, each wHTH DNA-binding domain and each metal-binding pocket are indicated by different forms colored in grey, respectively a polygon, a rectangle and a circle. (B) Close view of dimer interface. Protomers A and B of ZitRMG dimer are shown as in Fig 2A. Residues involved in dimerization are labelled and represented in ball-and-sticks, with N atoms colored in blue and O atoms in red. Hydrogen bonds are shown as dashed lines, either in black in most cases or in red when they involve main chain atoms.

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