10.1371/journal.pone.0072173.g010 Junji Okuda Junji Okuda Shinnichiro Niizuma Shinnichiro Niizuma Tetsuo Shioi Tetsuo Shioi Takao Kato Takao Kato Yasutaka Inuzuka Yasutaka Inuzuka Tsuneaki Kawashima Tsuneaki Kawashima Yodo Tamaki Yodo Tamaki Akira Kawamoto Akira Kawamoto Yohei Tanada Yohei Tanada Yoshitaka Iwanaga Yoshitaka Iwanaga Michiko Narazaki Michiko Narazaki Tetsuya Matsuda Tetsuya Matsuda Souichi Adachi Souichi Adachi Tomoyoshi Soga Tomoyoshi Soga Genzou Takemura Genzou Takemura Hiroshi Kondoh Hiroshi Kondoh Toru Kita Toru Kita Takeshi Kimura Takeshi Kimura The expression of genes related to mitochondrial function under the TAC operation. Public Library of Science 2013 Biochemistry enzymes Enzyme metabolism metabolism Carbohydrate metabolism Model organisms Animal models mouse cardiovascular Heart failure Diagnostic medicine pathology General pathology biomarkers genes mitochondrial tac 2013-08-12 02:22:15 Figure https://plos.figshare.com/articles/figure/_The_expression_of_genes_related_to_mitochondrial_function_under_the_TAC_operation_/769789 <p>The expression of genes related to mitochondrial energy metabolism was decreased in NTg mice with TAC. The genes presented here are (<b>A</b>) transcriptional regulators, (<b>B</b>) fatty acid metabolism, (<b>C</b>) the TCA cycle, and (<b>D</b>) mitochondria. Pgam2 overexpression further decreased the expression of some of these genes, such as ERRα, Tfam, MCAD, Cox5a, and Cox7a1 with TAC. Values are the mean ± SEM. N: NTg mice. P: Pgam2 mice. *p<0.05 versus the same genotype with the sham operation. †p<0.05 versus NTg mice with the same operation. Sham-operated NTg mice: n = 8; sham-operated Pgam2 mice: n = 8; NTg mice with TAC: n = 10; Pgam2 mice with TAC: n = 14.</p>