10.1371/journal.pone.0070527.g005 Tina Falkeborn Tina Falkeborn Andreas Bråve Andreas Bråve Marie Larsson Marie Larsson Britt Åkerlind Britt Åkerlind Ulf Schröder Ulf Schröder Jorma Hinkula Jorma Hinkula IL-2 release from splenocytes, stimulated with different antigens. Public Library of Science 2013 immunology immunity Adaptive immunity Humoral immunity Immune activation Immune defense Immunity to infections immunizations Innate immunity Immune response microbiology Virology Viral vaccines Clinical immunology vaccination vaccines Vaccine development Infectious diseases Viral diseases influenza stimulated 2013-08-08 02:54:22 Figure https://plos.figshare.com/articles/figure/_IL_2_release_from_splenocytes_stimulated_with_different_antigens_/767776 <p>Mice were immunized with a split influenza vaccine (Vaxigrip) containing the A/H1N1/Brisbane/2007 strain with or without adjuvant. The groups were immunized three times with three-week intervals. Splenocytes were analyzed regarding IL-2 release after influenza stimuli. (A) IL-2 responses against influenza A/H1N1/Brisbane/59/2007 (whole virus). (B) IL-2 responses against influenza A/H1N1/ California/04/2009 (whole virus). (C) IL-2 responses against influenza nucleoprotein-peptides from A/H1N1/Brisbane. Median and range is shown for each group and statistical significance compared to the non-adjuvanted group are indicated, *p<0.05, **p<0.01 and ***p<0, 001.</p>