Whole-genome sequence of the bovine blood fluke <i>Schistosoma bovis</i> supports interspecific hybridization with <i>S</i>. <i>haematobium</i>
Harald Oey
Martha Zakrzewski
Kerstin Gravermann
Neil D. Young
Pasi K. Korhonen
Geoffrey N. Gobert
Sujeevi Nawaratna
Shihab Hasan
David M. MartÃnez
Hong You
Martin Lavin
Malcolm K. Jones
Mark A. Ragan
Jens Stoye
Ana Oleaga
Aidan M. Emery
Bonnie L. Webster
David Rollinson
Robin B. Gasser
Donald P. McManus
Lutz Krause
10.1371/journal.ppat.1007513
https://plos.figshare.com/articles/dataset/Whole-genome_sequence_of_the_bovine_blood_fluke_i_Schistosoma_bovis_i_supports_interspecific_hybridization_with_i_S_i_i_haematobium_i_/7621661
<div><p>Mesenteric infection by the parasitic blood fluke <i>Schistosoma bovis</i> is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite <i>S</i>. <i>haematobium</i> with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the <i>S</i>. <i>bovis</i> genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of <i>S</i>. <i>bovis</i> and <i>S</i>. <i>haematobium</i> appeared strikingly similar with 97% sequence identity. The two species share 98% of protein-coding genes, with an average sequence identity of 97.3% at the amino acid level. Genome comparison identified large continuous parts of the genome (up to several 100 kb) showing almost 100% sequence identity between <i>S</i>. <i>bovis</i> and <i>S</i>. <i>haematobium</i>. It is unlikely that this is a result of genome conservation and provides further evidence of natural interspecific hybridization between <i>S</i>. <i>bovis</i> and <i>S</i>. <i>haematobium</i>. Our results suggest that foreign DNA obtained by interspecific hybridization was maintained in the population through multiple meiosis cycles and that hybrids were sexually reproductive, producing viable offspring. The <i>S</i>. <i>bovis</i> genome assembly forms a highly valuable resource for studying schistosome evolution and exploring genetic regions that are associated with species-specific phenotypic traits.</p></div>
2019-01-23 18:53:48
haematobium Mesenteric infection
interspecific hybridization
sequence
bovis genome assembly forms
form interspecific hybrids
DNA
species-specific phenotypic traits
blood fluke Schistosoma bovis
identity
374 Mb assembly