10.1371/journal.pcbi.1006646.t001 Carmen Lía Murall Carmen Lía Murall Robert Jackson Robert Jackson Ingeborg Zehbe Ingeborg Zehbe Nathalie Boulle Nathalie Boulle Michel Segondy Michel Segondy Samuel Alizon Samuel Alizon Parameter descriptions for epithelial model, default values, biologically realistic ranges and estimated values. Public Library of Science 2019 testing hypotheses ecology-inspired model pathogen load bottom-up processes Human papillomaviruses epithelial structure modeling approach cervicovaginal parameter estimates infection symptoms tissue cell cultures HPV 3 D tissue culture Epithelial stratification shapes infection dynamics Infections Chlamydia trachomatis estimate parameters infection dynamics infection strategies pathogen burden 2019-01-23 18:53:32 Dataset https://plos.figshare.com/articles/dataset/Parameter_descriptions_for_epithelial_model_default_values_biologically_realistic_ranges_and_estimated_values_/7621652 <p>Literature estimates (a) are for cervicovaginal epithelia, while data-derived estimates (b) are for NIKS cell cultures, which are a common cell-line used to model these systems, but are not identical to <i>in vivo</i> cells in the cervicovaginal squamous epithelium (for example the latter cannot form keratinized layers). Thus, estimates are not expected to be identical. Additionally, (a) parameters are measured from systems already at homeostasis, while in (b) the cultures grow-up from a single layer. Parameter values that were chosen for the results to be biologically consistent are labelled as ‘calibrated’. The values ‘fixed*’ and ‘estimated*’ were derived using data (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006646#pcbi.1006646.s006" target="_blank">S1 Text</a>).</p>