10.1371/journal.pcbi.1006646.t001
Carmen Lía Murall
Carmen
Lía Murall
Robert Jackson
Robert
Jackson
Ingeborg Zehbe
Ingeborg
Zehbe
Nathalie Boulle
Nathalie
Boulle
Michel Segondy
Michel
Segondy
Samuel Alizon
Samuel
Alizon
Parameter descriptions for epithelial model, default values, biologically realistic ranges and estimated values.
Public Library of Science
2019
testing hypotheses
ecology-inspired model
pathogen load
bottom-up processes
Human papillomaviruses
epithelial structure
modeling approach
cervicovaginal parameter estimates
infection symptoms
tissue cell cultures
HPV
3 D tissue culture
Epithelial stratification shapes infection dynamics Infections
Chlamydia trachomatis
estimate parameters
infection dynamics
infection strategies
pathogen burden
2019-01-23 18:53:32
Dataset
https://plos.figshare.com/articles/dataset/Parameter_descriptions_for_epithelial_model_default_values_biologically_realistic_ranges_and_estimated_values_/7621652
<p>Literature estimates (a) are for cervicovaginal epithelia, while data-derived estimates (b) are for NIKS cell cultures, which are a common cell-line used to model these systems, but are not identical to <i>in vivo</i> cells in the cervicovaginal squamous epithelium (for example the latter cannot form keratinized layers). Thus, estimates are not expected to be identical. Additionally, (a) parameters are measured from systems already at homeostasis, while in (b) the cultures grow-up from a single layer. Parameter values that were chosen for the results to be biologically consistent are labelled as ‘calibrated’. The values ‘fixed*’ and ‘estimated*’ were derived using data (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006646#pcbi.1006646.s006" target="_blank">S1 Text</a>).</p>