Minematsu, Asuka Miyazaki, Taiga Shimamura, Shintaro Nishikawa, Hiroshi Nakayama, Hironobu Takazono, Takahiro Saijo, Tomomi Yamamoto, Kazuko Imamura, Yoshifumi Yanagihara, Katsunori Kohno, Shigeru Mukae, Hiroshi Izumikawa, Koichi Synergistic effects of azole antifungals and the V-ATPase inhibitor bafilomycin B<sub>1</sub> against <i>C</i>. <i>glabrata</i> wild-type strain. <p>Checkerboard assay was performed using serial 2-fold dilutions of drugs. (A) Data for the combination of fluconazole and bafilomycin B<sub>1</sub>. (B) Data for the combination of voriconazole and bafilomycin B<sub>1</sub>. Plates were incubated at 35°C for 48 h and the optical density at 600 nm (OD<sub>600</sub>) was determined. The graphs are representative of three independent replicate experiments.</p> Candida albicans;antifungal agents;VPH 2;pH homeostasis;findings support;V-ATPase function;vacuolar membranes;reconstituted strains;plecomacrolide V-ATPase inhibitor bafilomycin B 1;iron limitation;Candida glabrata Vacuolar proton-translocating ATPase;Vacuolar proton-translocating ATPase;antifungal resistance;virulence;multidrug resistance;pathogen Candida glabrata;assembly factor;glabrata Δ vph 2;mouse model;intracellular ion homeostasis;azole antifungal agents;VPH 2 gene encoding;glabrata wild-type strain;calcineurin inhibitor FK 506;stress;antifungal strategies;acidic pH 2019-01-23
    https://plos.figshare.com/articles/figure/Synergistic_effects_of_azole_antifungals_and_the_V-ATPase_inhibitor_bafilomycin_B_sub_1_sub_against_i_C_i_i_glabrata_i_wild-type_strain_/7620569
10.1371/journal.pone.0210883.g001