Hsieh, Wen-Yeh Chang, Teng-Hsiang Chang, Hui-Fang Chuang, Wan-Hsuan Lu, Li-Che Yang, Chung-Wei Lin, Chih-Sheng Chang, Chia-Chu Body weights, serum and renal biochemical determinations in mice with AAI-induced acute nephropathy. <p>Animal model of nephropathy was performed in C57BL/6 mice. The mice were treated with AAI via intraperitoneal (i.p.) injection, and the accumulated AAI dosage was 45 mg/kg BW (15 mg/kg BW per day for 3 days). Five groups of 9 mice per group were used. Mouse body weights were recorded daily (<b>A</b>), changes in serum BUN and creatinine (<b>B</b>) levels, and urine protein and urine albumin <b>(C)</b> levels were determined. All values are expressed as the means ± SD of each group (n = 9). ** indicates <i>p</i> < 0.01 compared to the Control group; † and †† indicate <i>p</i> < 0.05 and <i>p</i> < 0.01 compared to the AAI group, respectively.</p> ACEI;angiotensin II formation;p-Smad 3 levels;BW;Ang II level;AAI-induced nephropathy progression;Ang II levels;kidney injury development;chymase hydrates Ang;Renal chymase-dependent pathway;ACE;aristolochic acid I-induced;CI;Ang II;nephropathy Angiotensin-converting enzyme;C 57BL mice;AAI-treated mice;role;AAI-induced nephropathic mice;Renal RAS-related enzyme activities 2019-01-11
    https://plos.figshare.com/articles/figure/Body_weights_serum_and_renal_biochemical_determinations_in_mice_with_AAI-induced_acute_nephropathy_/7579628
10.1371/journal.pone.0210656.g001