Body weights, serum and renal biochemical determinations in mice with AAI-induced acute nephropathy.
Wen-Yeh Hsieh
Teng-Hsiang Chang
Hui-Fang Chang
Wan-Hsuan Chuang
Li-Che Lu
Chung-Wei Yang
Chih-Sheng Lin
Chia-Chu Chang
10.1371/journal.pone.0210656.g001
https://plos.figshare.com/articles/figure/Body_weights_serum_and_renal_biochemical_determinations_in_mice_with_AAI-induced_acute_nephropathy_/7579628
<p>Animal model of nephropathy was performed in C57BL/6 mice. The mice were treated with AAI via intraperitoneal (i.p.) injection, and the accumulated AAI dosage was 45 mg/kg BW (15 mg/kg BW per day for 3 days). Five groups of 9 mice per group were used. Mouse body weights were recorded daily (<b>A</b>), changes in serum BUN and creatinine (<b>B</b>) levels, and urine protein and urine albumin <b>(C)</b> levels were determined. All values are expressed as the means ± SD of each group (n = 9). ** indicates <i>p</i> < 0.01 compared to the Control group; † and †† indicate <i>p</i> < 0.05 and <i>p</i> < 0.01 compared to the AAI group, respectively.</p>
2019-01-11 18:36:51
ACEI
angiotensin II formation
p-Smad 3 levels
BW
Ang II level
AAI-induced nephropathy progression
Ang II levels
kidney injury development
chymase hydrates Ang
Renal chymase-dependent pathway
ACE
aristolochic acid I-induced
CI
Ang II
nephropathy Angiotensin-converting enzyme
C 57BL mice
AAI-treated mice
role
AAI-induced nephropathic mice
Renal RAS-related enzyme activities