Body weights, serum and renal biochemical determinations in mice with AAI-induced acute nephropathy. Wen-Yeh Hsieh Teng-Hsiang Chang Hui-Fang Chang Wan-Hsuan Chuang Li-Che Lu Chung-Wei Yang Chih-Sheng Lin Chia-Chu Chang 10.1371/journal.pone.0210656.g001 https://plos.figshare.com/articles/figure/Body_weights_serum_and_renal_biochemical_determinations_in_mice_with_AAI-induced_acute_nephropathy_/7579628 <p>Animal model of nephropathy was performed in C57BL/6 mice. The mice were treated with AAI via intraperitoneal (i.p.) injection, and the accumulated AAI dosage was 45 mg/kg BW (15 mg/kg BW per day for 3 days). Five groups of 9 mice per group were used. Mouse body weights were recorded daily (<b>A</b>), changes in serum BUN and creatinine (<b>B</b>) levels, and urine protein and urine albumin <b>(C)</b> levels were determined. All values are expressed as the means ± SD of each group (n = 9). ** indicates <i>p</i> < 0.01 compared to the Control group; † and †† indicate <i>p</i> < 0.05 and <i>p</i> < 0.01 compared to the AAI group, respectively.</p> 2019-01-11 18:36:51 ACEI angiotensin II formation p-Smad 3 levels BW Ang II level AAI-induced nephropathy progression Ang II levels kidney injury development chymase hydrates Ang Renal chymase-dependent pathway ACE aristolochic acid I-induced CI Ang II nephropathy Angiotensin-converting enzyme C 57BL mice AAI-treated mice role AAI-induced nephropathic mice Renal RAS-related enzyme activities